Tailoring Resorption Rates and Osteogenic Response in Xeno-Hybrid Bone Grafts: The Effect of Added Gelatins

Bone defects resulting from trauma, surgery, congenital malformations, and other factors are among the most common health problems nowadays. Although current strategies such as autografts allografts recognized successful treatments for stimulating bone regeneration, limitations graft source complications still exist. SmartBone® is a xeno-hybrid (made bovine matrix, poly(L-lactic-co-?-caprolactone), gelatin) with positive clinical record regeneration. In this study, formulation designing grafts using gelatins different sources (bovine- porcine-derived gelatin, named SBN SPK, respectively) was investigated, biological responses were evaluated in vitro vivo. The results demonstrate that both porcine can be loaded onto successfully safely, withstanding aggressive manufacturing processes. Different cell observed vitro. found to enhance osteocalcin secretion while SPK upregulate osteopontin human osteoblasts. vivo, promoted osteogenesis, but degraded earlier than SBN. Our findings suggest provide yet comparable solutions optimizing resorption regeneration balance. These possess ideal potential defect repairing.